Two men were shot and seriously injured Wednesday night on the 3100 block of Mission Street, between Cesar Chavez and Valencia.
The shooting happened around 10:20 p.m., and both men's injuries are considered life-threatening, as Bay City News reports.
KPIX reports that witnesses heard a total of six gunshots.
No information is yet known about the victims or their ages, and no suspects are in custody.
The block of Mission on which the shooting occurred is a highly trafficked one, and home to businesses including Baby Blues BBQ, El Rio, and Roccapulco.
Anyone with information about the incident is asked to call San Francisco Police anonymously at 1-415-575-4444, or text-a-tip to TIP411 with SFPD at the start of the message.