FILM: DocFest kicks off tonight with Dirty Pictures, about Dr. Alexander “Sasha” Shulgin, "the rogue chemist who discovered the effects of MDMA (aka Ecstasy) and over 200 other mind-altering drugs," earning him the title of “The Godfather of Psychedelics,”. The film is followed by an opening night party at CellSpace. (7 p.m., Roxie Theater, 3117 16th Street)

ART: 2 Blocks of Art, which is book-ended by Luggage Store gallery at one end, and 1st Amendment gallery (1:AM) at the other, features 50 artists in 25 locations - all within 2 blocks, including musicians playing in a Laundromat and a fashion designer exhibiting in an optometry office. (4 to 8 p.m., Sixth Street between Market and Howard)

BENEFIT: Beats for Boobs presents its 8th annual benefit, which brings together the best in local DJs, artists, fashion designers, and culinary masterminds to raise funds for various local breast cancer programs. (6 p.m. to 2 a.m., Mezzanine, 444 Jesse Street)