The Trump administration sent layoff notices Tuesday to around 10,000 employees of the US Department of Health and Human Services, including dozens who work out of the Speaker Nancy Pelosi Federal Building in San Francisco.

As the slashing and burning of federal agencies continues under Trump, Musk, and RFK Jr., Tuesday was layoff day for Health and Human Services (HHS), which oversees agencies including the Centers for Disease Control and the Food and Drug Administration. The Department began with about 82,000 employees this year, and with around 10,000 voluntary departures since Trump took office, today's layoffs are expected to bring the employee rolls at HHS down to around 62,000, per the New York Times.

Some employees, including some senior officials at the FDA, reportedly learned they'd been let go when their badges didn't work to scan them into offices today, the Times reports.

The 318 workers who staff the San Francisco regional offfice of HHS will either be laid off or relocated, and the SF office will be closed, as the Chronicle reports. Speaker Emerita Nancy Pelosi has issued a statement about the move, saying, "This shortsighted office closure would lead to critical service slowdowns for San Franciscans to get the resources they need and detrimental impacts to our public health response capabilities – all in the name of so-called 'government efficiency.'"

She added, "Make no mistake: the reported plans to restructure HHS and close the San Francisco regional office would directly harm our most vulnerable communities and make America sicker."

The SF office of HHS oversees Medicare, Medicaid, and health services for Native Americans, as well as and HIV/AIDS programs for Arizona, California, Hawaii, Nevada, six American territories and around 160 federally-recognized tribes.

I guess since RFK is cracking down on poppers, which he thinks cause HIV, we don't need these services anymore.

The Times reports that teams leading HIV surveillance and research within the CDC were also laid off today, as were "a group of global health researchers who were working on preventing mother to child transmission of HIV."

Communications offices at all the agencies under HHS were reportedly also hit hard. And the official word from the press office at HHS was that the department "is centralizing communications across the department to ensure a more coordinated and effective response to public health challenges, ultimately benefiting the American taxpayer."

In a March 27 statement, RFK said, "We aren't just reducing bureaucratic sprawl. We are realigning the organization with its core mission and our new priorities in reversing the chronic disease epidemic."

The slashing of broad swaths of the FDA and CDC have to be alarming to members of Congress, particularly given RFK's utter lack of qualifications for the secretary job, and given that zero analysis has been done — or at least been made public — about the rationale for these layoffs.

The closing of the San Francisco office seems particularly arbitrary and part of Trump's continued attack on the city itself. RFK has said he plans to reduce the number of regional HHS offices from ten to five.

Per the Chronicle, around 70 of the workers in the SF office of HHS were told that their divisions were closing. It's unclear what the total local layoff number will be, but other employees of the office were reportedly told that their jobs would be relocated to Denver.

While the Speaker Nancy Pelosi Federal Building was removed from the DOGE shortlist of buildings to be sold off, for now, it seems far from safe in the long term — especially because Trump hates contemporary architecture.

Also housed in the building are Pelosi's own local office, and regional offices for the Social Security Administration, and the Departments of Transportation, Labor, Agriculture, and Housing and Urban Development.

Related: San Francisco Federal Buildings Spared, For Now, as GSA Pares Down Its List of Real Estate to Sell